![]() ![]() Almost all of these agents are excreted through the kidneys without any significant metabolic change in the body. They are also helpful in dynamic imaging to assess the preferential enhancement of certain pathologic processes, such as hepatocellular carcinoma or renal cell carcinoma. Thus, these agents are suitable for imaging disease processes that disrupt the blood-brain barrier, such as cerebral tumors or cerebral infectious processes. They do not cross the normal blood-brain barrier. These complexes are of low molecular weight and weakly bind to proteins and thus circulate within the intravascular space for a very short period of time before leaking into the extracellular space. The reduction in the T1 relaxation time is greater at low gadolinium concentrations than is routinely achieved clinically this is seen as increased signal intensity on T1-weighted spin-echo or gradient-echo images. This strong paramagnetic effect disturbs the relaxivity of nearby water protons, resulting in a decrease of both T1 and T2 relaxation times. ![]() Gadolinium is a paramagnetic agent because of its seven unpaired electrons. They are classified into four groups depending on the charge (ionic or nonionic) and the biochemical structure of the complex (macrocyclic or linear) (2) (Table 1). Essentially all these agents have gadolinium (a paramagnetic metal in the lanthanide series) as the active component attached to various complexes that determine their charge, pharmacokinetics, biodistribution, and toxicity. These are the first-generation MR contrast agents. Nonspecific extracellular MR contrast agents The non-tissue-specific contrast agents have an initial short intravascular distribution and then distribute in the extracellular space throughout the body without any selective accumulation in an organ. As the name implies, tissue-specific contrast agents are targeted at a specific tissue type (eg, reticuloendothelial cell-specific or hepatocyte-specific) or organ (eg, blood-pool agents for the vascular system or enteral agents for bowel). MR contrast agents are primarily classified into two groups based on their organ specificity-tissue-specific contrast agents and non-tissue-specific contrast agents. In this article, we review various MR contrast agents in clinical use and in development and their current and potential applications. ![]() The resulting capability for shorter MR image acquisition times can allow functional studies, such as MR perfusion, to be performed with better time resolution. Contrast agents may also find further novel applications at high field strengths (>1.5T). In addition, the contrast agents are used for depicting normal and abnormal vasculature or flow-related abnormalities and pathophysiologic processes like perfusion. These contrast agents are used primarily to increase the sensitivity of MR for detecting various pathological processes and also for characterizing various pathologies. (1) MR contrast agents contain paramagnetic or superparamagnetic metal ions that affect the MR signal properties of surrounding tissue. Today, 40% to 50% of all MR examinations use contrast agents. Since the introduction of the first MR contrast agent in 1988, there has been a tremendous increase in the number of contrast-enhanced examinations. Magnetic resonance (MR) contrast agents have made a significant impact in the use of MR imaging for various clinical indications. ![]()
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![]() ![]() Starsong flies after the dragon, but stops short when she sees it go toward Willy Nilly mountain. Pinkie Pie breaks up their squabble to point out they're going to need to work together to get Twinkle Wish back, a plan which had not occurred to Cheerilee, apparently. The older ponies crowd around the box to admire it, leaving Scootaloo and Sweetiebelle out of the loop, so they use a trampoline to sneak a peek while the others talk about how they want to see Twinkle Wish again, but know they have to wait.Īt first, Cheerilee is down on herself for letting this happen, but she quickly turns on her little sister, who in turn blames it on everyone not letting her get a good look at the box. She officially passes the box to Cheerilee, tells her "The fate of the festival is in your hands," and then rides off again. The reason the mayor gives is that Twinkle Wish is asleep, and waking her too soon means she won't have enough power to grant everyone's wishes. The mayor rides up to them in her scooter to give Cheerilee the box containing Twinkle Wish, which must absolutely positively not be opened until the next day at sunset, which marks the beginning of the Winter Wishes Festival. After the ceremony, as the ponies walk home, Scootaloo is all pouty, but the others tell her "There's always next year," which she does not appreciate. Anyway, this year's theme is "Ponyville's Spirit of Friendship," so naturally Cheerilee wins, and the mayor even makes a point of singling out the button. Is it just me, or is she totally Scootaloo's (and by extension, Cheerilee's) mom? Nobody makes mention of this, so I'm guessing not, but come on, she's got the right color scheme and the big hair to match. At last Mayor Flitter Flutter arrives (with a teased-up hairdo) to pick the winning ornament. Everyone except Scootaloo is certain Cheerilee will win, though a win for her will be like a win for all of them, really. Later that afternoon, the core seven gather in the square again to await the announcement of the winning ornament. While showing off their ornaments to each other, they finally realize Cheerilee isn't there, and go to find her. In the meantime, everyone tries to figure out how to beat the designated Artsy pony (Toola Roola), which for the Rainbow/Starsong team is more glitter and feathers, and for Scootaloo/Sweetiebelle, a lucky button. Though Pinkie Pie gets the feeling they're forgetting something, it isn't all their ornaments are made that they realize just what it is. The others propose to combine their various stuff (pink, colorful, glittery, and stuffy) and meet up at Sweetiebelle's house, while Cheerilee dejectedly goes to her own house to work on her ornament alone. The narrator handily points out that none of the others left her out on purpose. Cheerilee suggests they all pair up, conveniently forgetting that there are seven of them, and predictably, she ends up the odd pony out. With the contest coming up later that day, Toola Roola gets half an idea for an ornament, and Pinkie Pie suggests they team up, since she has too many ideas. Scootaloo and Sweetiebelle make a big deal of "not being little," which just makes the others laugh, though Scootaloo is placated easily enough by being told she's cute. Cheerilee continues to explain about the ornament making contest, the winner of which gets the honor of placing the star, which grants everyone in town one wish, at the top of the tree. ![]() Sweetiebell and Scootaloo, as the youngest, speculate on the tree's name, though Cheerilee sets them straight, while the others just giggle at their ignorance. Being as this is a Christmas special, we open with a scene of snowflakes, although once the camera pan gets to Ponyville, there isn't any snow, and a pony makes a point of saying "I wish it would snow." A random narrator begins to give us the exposition on the Winter Wishes Festival, and the core seven burst in with their favorite "holiday" traditions (parties, outfits, hairstyles, cookies, painting, skating, decorations), but the narrator insists that the best is putting the Twinkle Wish star on top of the Christmas Ever Forevergreen Tree in the town square. However, there's an extended version on the DVD that includes the animation not used, along with even more scenes and an all-new bridge. It starts off with the theme song, but with slightly different animation from the version available on Hasbro's website, which I've covered already. ![]() ![]() ![]() as part of imparting promotion of cultural activities in the field of art has also been associated with RR Sabha as a president. He has made worthwhile contribution including financial support in the construction of new building for the Sabha which is currently in progress.A.R.S. ![]() Left unattended, these divergences among managers will undermine the company’s effort for uniform merit-based practices.Mr.A.R.Santhanakrishnan (A.R.S.), Aged 69 Years is a Science Graduate and holds a Hons. Managers have different personal and professional experiences, and as shown by this study, those different experiences can lead to different concepts of what merit should entail. What is most important is that companies ensure that all managers agree on a clearly articulated definition of merit. What are the merit-based processes used in the company’s hiring efforts, for example? How are merit-based rewards designed? Companies need to pay close attention to how merit is measured and operationalized in the organization. The results of the study offer important lessons for companies trying to base their hiring, rewards, and promotions on merit. Both the focused and diffuse approaches were fully represented in the company. Of the 52 managers interviewed, 41 worked for the same company, thus ensuring that company or industry characteristics did not explain the different approaches. The study was based on in-depth interviews of 52 managers as well as qualitative reviews of a further 56 managers. Managers who perceive their evaluation experiences as mostly positive, on the other hand, will take the broader, diffuse approach: they evaluate work actions but also personal qualities, use both quantitative and qualitative measures, and evaluate individual performance in the context of a larger whole (e.g., a group or team). Managers who perceive their evaluation experiences as mostly negative will take a narrow, focused approach: they evaluate work actions only, use quantitative measures, and focus on the individual level. The result is two very different approaches to evaluating merit: focused and diffuse. Rectify the unfairness that they experienced if their evaluation outcomes were perceived as mostly bad.Reproduce the fairness that they experienced as employees if their evaluation outcomes were perceived as mostly good, or.When employees become managers and start to make merit-based decisions, they want to either ![]() Over time, employees solidify their understanding of merit based on these positive or negative evaluation experiences. In contrast, an employee who loses a promotion to another employee because the other person is considered more likable will consider that any evaluation of merit should exclude personal qualities such as likability. Following negative outcomes, employees will exclude in their understanding of what constitutes merit the decisive factors that led to the negative outcome.įor example, an employee who is promoted in part because of his or her likability (in addition to positive actions and results) will consider that personal qualities should be included when deciding merit. Following positive outcomes, employees will include in their understanding of what constitutes merit the decisive factors that led to the positive outcome. The source of these different views of merit is found, according to the research, in the evaluation experiences of the managers when they were employees-experiences that for most managers were perceived as either mostly good (leading to positive outcomes) or mostly bad (leading to negative outcomes).īased on the outcomes, employees form different understandings of merit. These differences are these different definitions or understandings of merit diverge in terms of content (for example, accomplishments only or accomplishments and personal attributes), metric (for example, qualitative measures versus quantitative measures), and unit (that is, the merit either involves the individual only or the individual and the team). The study showed that different managers have different ideas of what constitutes merit. For example, studies continue to show that women and minorities are paid less than their white male counterparts.Ī study from MIT and Berkeley offers one explanation for why companies and organizations are not living up to their meritocratic goals. However, the practice of meritocracy doesn’t often live up to the aspiration. Meritocracy is an ideal that today’s organizations strive for. Different evaluation experiences as employees can lead managers to different ideas about merit, complicating efforts for companies trying to establish merit-based processes for hiring, promoting, or rewarding people. ![]() ![]() ![]() So, when it is on your computer, you won't have to run to the service center for each minor issue that arises during your iOS experience. IToolab FixGo is quite a valuable tool for iPhone users. ![]() And if you are satisfied with the tools after using these plans, purchase the lifetime package. But, if you are on a one-year program, the price would be $39.95. The cost of itoolab fixgo is $29.95 if you choose the one-month plan. But when you reach the final steps, it will ask you to purchase the complete version. You can fix your issues in the standard or advanced mode. Although the iToolab Fixgo download for windows doesn't cost anything, and you can enter or exit iPhone recovery mode free of charge, you have to buy its license when use the two modes to fix your Apple devices. So, before you use it, make sure you have backed up your data in cloud storage or on a computer. Remember, the advanced mode will wipe away all the data from your device. However after connecting your device to the PC/Mac, you will select the Fix iOS System- Advanced Mode from the left instead of the standard mode. However, if the problem is unsolvable in Standard Mode, you must use the Advanced Mode. These steps will complete the process and solve common issues (black or white screen, frozen in recovery mode, boot logo, etc.). The subsequent screen confirms successful download. Select Download if you haven't already downloaded it. A screen appears saying Download Firmware. Put the device in recovery mode or DFU mode. ![]() Select the tile Fix iOS System – Standard Mode. 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Free Download itoolab FixGo full version standalone offline installer for Windows, it will prevent data loss on your iPhone or iPad. ![]() ![]() ![]() Echo Show 5 (2nd Gen): What’s the difference?Ģnd-gen vs. Amazon Echo Dot (5th-gen)Įcho Show 5 (1st Gen) vs. To find out where you can buy a Kevo of your own (for the price of $229), check out /kevo. Kwikset 99390-001 Halo Wi-Fi Smart Lock Keyless Entry Electronic Touchscreen Deadbolt Featuring SmartKey Security, Satin Nickel. And because the Kevo Smart Lock integrates with everything from the Nest Thermostat to the Skybell HD Doorbell, you can configure a smart home starting at your door.Īvailable in three different finishes (Satin Nickel, Venetian Bronze, and Polished Brass), customers will be able to pick a lock that best fits their aesthetic. I did that several times and it didnt change anything. Most of their older locks are basic pin tumbler locks, but their new Smartkey locks operate on a similar but. To control front room door, try disabling the skill and then reenabling it from your Alexa app. Moreover, the app will provide lock notifications and activity history so home owners can keep tabs on who’s entering and leaving their house. Kwikset manufacturers several types of locks. The associated Kevo app lets users manage home access for other family members, friends, and guests, by sharing electronic keys. “I truly believe the time to buy Kevo is now for any consumer waiting for technology to evolve before purchasing a smart lock.” ![]() ![]() “Kwikset listened to homeowners’ everyday experience with Kevo first-gen and put their feedback at the center of the Kevo second-gen development strategy,” said Keith Brandon, Kwikset’s vice president of residential access solutions. Google Nest Hub (2nd Gen)Įcho Plus (1st-gen) vs. And for even more options to protect your front door, check out our smart lock ratings.Echo Show 8 (1st Gen) vs. The models that fail-at least half do-go through another round, this time with a reinforced box strike plate (a basic DIY upgrade that improves security) installed on a new lock sample.įor more on our tests and what to consider as you shop, see our door lock buying guide. They repeat the test eight times, with the ram raised to increasing heights or until the lock fails. To evaluate both smart and conventional locks, CR engineers conduct kick-in tests using a custom-built jig that swings a 100-pound steel battering ram against a locked door. The remaining picks are WiFi-capable smart locks, which connect directly to WiFi, or through a WiFi adapter or smart home hub. Another two picks are Bluetooth-only smart locks, meaning they don’t come with a WiFi adapter (one model offers an adapter sold separately), so you can’t control and monitor the lock when you’re away from home. Because the exterior part of your deadbolt will remain, you can still use your physical keys but also lock and unlock the door from a smartphone app. 816 Single Cylinder Satin NIckel Key Control Deadbolt Featuring SmartKey Security with Microban Antimicrobial Technology. SmartKey Security with convenient re-key. Kwikset Smartkey locks are only compatible with Kwikset factory-cut keys or professional lock-smith generated keys carefully cut to factory specs. Up to 250 user codes with a 10-button keypad. Works with Z-Wave 700 panels and hubs (will also work with existing Z-Wave 500 panels and hubs). You’ll find models from August, Bosma, Eufy, Kwikset, Wyze, and Yale.įour of our picks are retrofit smart locks, which only replace the part of the lock that’s on the interior side of your door. Best overall : Kwikset Home Connect 620 Keypad Connected Smart Lock. “Depending on the model, you can view the status of your lock from anywhere and track who opens your door and when.”īelow you’ll find the 10 best smart locks from our tests, listed alphabetically and split into three categories. “Smart locks can add an invaluable level of peace of mind,” says Misha Kollontai, CR’s test engineer for door locks. There are even some models with built-in fingerprint scanners, allowing you to unlock your door the same way you unlock your smartphone, with the tap of a finger. With both methods, you can create, revoke, delete, and limit them to certain time periods with a few swipes on your smartphone. 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In addition to being a challenging single-player experience, Cyber Lemur can also be a great party game. ![]() The game is designed to help the user to gradually improve their character control through a variety of level designs. But if you are to survive this harsh life on the frontier, you must first prove yourself to be a skilled mech pilot.Ĭyber Lemur falls in the "Intentionally Awkward Controls" category, with the twist of cooperative character control. This has allowed them to expand beyond the desolate landscape of earth, and to begin colonizing the moon. After millennia of evolution, lemurs have become increasingly intelligent and developed advanced cybernetic technologies. You will then use your new-found aptitude to compete in races or time trials, make record-breaking jumps, or vanquish your foes with the sheer power of physics.Ĭyber Lemur is set in a dystopian future where humans are extinct and lemurs have emerged as the dominant species. Trust me, as you get into the later levels you'll be spending quite a while on them Even then, the value is great. Game and want to purchase it, you can support the developers by doing so here.Have you every dreamed of maneuvering an intricate mechanical beast across daunting obstacles? Or fighting other mechs in hand-to-hand combat? If so, this may be the game for you! Cyber Lemur will teach you to re-wire your brain to the challenging mech controls, and become one with the mech. In terms of the amount of gameplay, it really is astonishing for the 14.99 price point. This download is completely free and won't cost you a penny. Then, launch the game through the desktop shortcut. Jump your way through insane levels in a game of the floor is lava on top of speeding trucks driven. No download or installation needed to play this game. That seems challenging enough in itself but these lorries aren't exactly being driven responsibly. Cluster Truck is a Physics Game you can play online for free in full screen at KBH Games. Double click inside the Clustertruck v2.1.0.3 folder and run the setup application. Clustertruck is a chaotic physics-based truckformer. ClusterTruck Gameplay - Free To Use No Copyright Gameplay 102K subscribers Join Subscribe 323 Share Save 9. Clustertruck is a unique platformer game in which you control a character leaping from the back of one moving vehicle to another in order to avoid touching the ground. ![]() zip file and click on “Extract to Clustertruck v2.1.0.3.zip” (To do this you will need 7-Zip, which you can get here, or you can use the built in windows extractor). ![]() Once the game is finished downloading, right click the.(You can use FDM which is free here, or any other download manager). EASY TO HARD Lets Play Clustertruck - Custom Maps User Level Gameplay Thalion 1. You need to enable JavaScript to run this app. No matter what you crave, we make it all fresh in our own kitchenjust minutes before it’s in your hands. We recommend using a download manager for faster download speeds. ClusterTruck is a delivery-only restaurant with a menu inspired by the best street food in the nation. With precise controls, hectic gameplay, and a solid game engine this is a. Wait 5 seconds and click on the blue ‘download now’ button. Clustertruck is a First-Person platformer that goes beyond any other.abilities remains on the screen during gameplay in semi-transparent form for the remainder of the session. Click the Download button below and you will be redirected to UploadHaven. A page for describing YMMV: Clustertruck.Clustertruck is a new kind of platformer on-top of a speeding highway! Use agility and acrobatics through insane levels in a game of “the floor is lava” on top of unpredictable, speeding trucks! The game only gets harder when dangers such as swinging hammers, lasers and flamethrowers are added! ![]() ![]() These may all be special cases of what Grothendieck described. ![]() (b) There are some cases where just a single map or similar gives you a filtered complex. (It is an acyclic resolution as VA says.) If you have a stratification that you wish was CW but isn't, then you just have a general filtered complex. A CW complex is stratified, but it has a special structure so that its chain complex doesn't need a spectral sequence. For instance it could be a stratified topological space. To discuss things more concretely, (I am told that VA's interesting answer is not a generalization of this paragraph.) For question (1), here are two general ways that filtered complexes show up: (a) you might get a filtered complex if you are interested in a chain complex that comes from a filtered object. Probably it is just more general than what I was going to say. VA gives a very general motivation for why filtered complexes show up so much. Two questions that remain are, (1) why do filtered complexes show up so much, and (2) is there anything that you could do with a filtered complex other than compute its spectral sequence? Qiaochu links to a really nice article by Timothy Chow that says a lot about the mechanics of how to go from a filtered complex to its spectral sequence. The spectral sequence gives you a way to deal with this situation. You can do the first step and the second step separately but they are not exactly independent of each other. Instead, they are made (via an appropriate filtration) from some other elementary, "acyclic" objects. $F(A)$ in case 2) is made of parts which are not themselves elementary. The reason for the spectral sequences in both cases is the same. Answer: Grothendieck's spectral sequence.ġ and 2 account for the vast majority of applications of spectral sequences, and provide plenty of motivation - I am sure you will agree. Let us say you know the derived functors for $F$ and $G$ and would like to compute them for the composition $GF$. Let us say you have two functors $F:\mathcal A\to\mathcal B$ and $G:\mathcal B\to \mathcal C$. ![]() If $J^n$ are not acyclic, you get a spectral sequence instead, and that's the best you can do. derived functors $R^nF$), you can use this resolution to compute the cohomologies of $A$ (resp. Let's say you have a resolution $0\to A\to J^0\to J^1\to\dots$ (of a module, a sheaf, etc.) If $J^n$ are acyclic (meaning, have trivial higher cohomology, resp. ![]() ![]() ![]() One of the major complaints about tablature used to be that it didn't show any timing value so you had to have heard the tune first before you could use the 'finger-map' of the tablature to play it. It is an excellent medium because it shows exactly where to place your fingers to find the notes and these finger placements are often the best way to find the notes to make the movement of your fretting hand the easiest and simplest as well as the most economical and efficient. Tablature is an excellent way in which to put guitar compositions and arrangements onto paper for learning and teaching purposes, and also to enable you to remember tunes from one year to the next, a definite factor if a tune isn't played for a year or two, especially as one gets a little older. McWilliam's Guitar Arrangements & Compositions (TablEditĪll the tunes here are played by: Steve J. take a listen to the various play-lists here: Many of the tunes on this page can be seen playing in TablEdit on YouTube at:Ī few of the tabs here can be heard on the YouTube Channel showcasing old recordings from the member of the Tape 'n' Tab Club (T'n'T) which were originally recoded on cassestte tapes If you let me know they are up I will includeĪ link to the video from this and other tab pages to ensure you obtain the maximum McWilliam (SteveMcBill)) as the tabber and also the relevantĬomposer and arranger of the tunes. It would be appreciated if you could acknowledge Vista, Win-7, Win-8, Win-8.1 and Win-10).Īnyone feel like putting up videos of their playing of these tunes on YouTube then please do feel free to do so. Version runs on Windows machines (Win-95, 98, ME, XP, NT, Win-2000, To allow you to see, play, print and use all of the TablEdit (.tef) musicįiles available on this site and elsewhere on the Internet. You to both play them through your computer speakers and to print them: Show you the TablEdit files/tunes in tab and/or music format and will allow The new TablEdit File Viewer - ' TEFView' - a free viewer which will Or a similar program, to unpack the files on your hard-drive. Those downloading the Zipped versions of the tabs should then use 7-Zip, WinZip, PKZip, You will need the full TablEdit program, or the new free TefView (see below) program, to be able to print and/or play these tablature downloads. Please do play the midi files and/orĭownload the TablEdit tablature for any of the tunes below, have fun playing See the tablatures the software is excellent. Do have a look at the TablEdit Demo, it will let you play and Registration details for the full version of the software can be found at This demo will allow you to play back TablEdit tab files and you can nowĭownload in excess of 10,000 tunes in this format from the TablEdit library ![]() ![]() It as a Midi File, can be obtained in Demo form for free at TablEdit. Print it out, as well as play it through your computer's speakers and to export You to input tablature for many stringed and other acoustic instruments and to Tablature shown below is in TablEdit format. ![]() |
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